Despite these risks, most people with factor V Leiden never develop abnormal clots, and most women with factor V Leiden have normal pregnancies. Nonetheless, if you have a family history of factor V Leiden and plan to get pregnant, you should be tested.
No test can tell you if or when you will develop a blood clot. Most people with a genetic risk for clotting live their entire lives without ever having a clotting event. Your chance to develop a serious blood clot depends on which protein is not working normally and whether or not you have other risk factors.
Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs. Most people with factor V Leiden never develop abnormal clots.
Hereditary thrombophilia is a common cause of thrombosis and is diagnosed by genetic testing. It can be caused by one of a number of genetic mutations which can change the proteins involved in the blood coagulation cascade. This leads to an increased risk of inappropriate blood clotting and thrombophilia.
A particular mutation in the F5 gene causes factor V Leiden thrombophilia. The F5 gene provides instructions for making a protein called coagulation factor V. This protein plays a critical role in the coagulation system, which is a series of chemical reactions that forms blood clots in response to injury.
A hereditary thrombophilia results when an inherited factor, such as antithrombin or protein C deficiency, requires interaction with components that are inherited or acquired before onset of a clinical disorder [3].
Factor V deficiency is also known as Owren's disease or parahemophilia. It's a rare bleeding disorder that results in poor clotting after an injury or surgery. Factor V deficiency shouldn't be confused with factor V Leiden mutation, a much more common condition that causes excessive blood clotting.
Factor V Leiden is a completely different inherited disorder in which factor V is mutated in a specific gene, which results in a hypercoagulable state. The mutation is very common, occurring in 5% of the US population. Factor V activity levels in patients with factor V Leiden are usually normal.
It is important that people with Factor V deficiency should not use Non-Steroidal Anti-Inflammatory Drugs (NSAIDs such as ibuprofen) as this greatly increases the risk of bleeding. Other methods of pain relief should be used instead.
People who have deep vein thrombosis are at risk for pulmonary embolism or stroke, both life-threatening conditions, and are sometimes advised not to work. Depending on their particular condition, they may qualify for disability benefits from Social Security.
People with factor V Leiden may donate blood, platelets or plasma safely, as long as they are not on an anticoagulant such as warfarin. Only a very few medicines prevent people from donating blood.
Inheritance of factor V Leiden and prothrombin G20210A. Genetic mutations are passed from generation to generation, because we receive our DNA from our parents. Our genetic information is inherited in pairs.
The coagulation factor V Leiden mutation, leading to resistance to activated protein C (APC), is the most common inherited risk factor for venous thrombosis. In various systemic autoimmune diseases the hypercoagulable state was shown to be associated with the presence of antiphospholipid antibodies (aPL).
Factor V Leiden is the most common inherited form of thrombophilia. Between 3 and 8 percent of the Caucasian (white) U.S. and European populations carry one copy of the factor V Leiden mutation, and about 1 in 5,000 people have two copies of the mutation.
Using Push Health, you can easily request a Factor V Leiden (G1691A) Mutation test from a licensed medical provider, get tested at a lab near you, and get results electronically. The total fees are $167.68 and include the lab order, lab fees and an electronic copy of the results.
Heterozygous means that the 2 copies of a gene are different. In your case, one of your Factor V gene codes is for normal clotting Factor V and the other Factor V gene code is for Factor V Leiden. There is more risk of a blood clot if both gene codes are for Factor V Leiden (ie in the homozygous state).
Thrombophilia is a condition that increases your risk of blood clots. It's usually treated with anticoagulant medicines.
