Commercially available options include dopamine-2 antagonists such as promethazine and prochlorperazine (Compazine), as well as 5-hydroxytryptamine-3 antagonists such as ondansetron (Zofran) and granisetron (Kytril). For motion sickness, scopolamine is a highly effective anticholinergic agent.
You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
Promethazine will be mostly out of your system in two to four days . The elimination half-life of a medication is the time it takes for blood levels of the medication to be reduced by half. For Promethazine the half-life is approximately 10 to 19 hours.
Drowsiness, dizziness, lightheadedness, blurred vision, constipation, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Zofran (ondansetron) begins to work within about 30 minutes. It reaches peak blood concentrations in about 2 hours. Zofran's effects can last 8 to 12 hours. The Zofran dosage varies depending on the severity and cause of the nausea and vomiting.
Prochlorperazine starts to work in around 30 to 60 minutes. If you're taking it for Ménière's disease, it will take a few days before it reaches its full effect.
Zofran (ondansetron) and Compazine (prochlorperazine) are prescribed for the treatment of nausea and vomiting. Zofran is often used to prevent and treat nausea and vomiting during chemotherapy and after surgery. Compazine is also used to treat psychotic disorders such as schizophrenia and anxiety.
Common side effects associated with Zofran include headache, drowsiness, constipation and the chills. In clinical trials of patients taking Zofran to prevent nausea and vomiting associated with chemotherapy, nearly a quarter of patients taking 8 mg of the drug twice daily experienced a headache.
However, if the chemotherapy is likely to cause nausea and vomiting, your doctor may prescribe one or more of the following common anti-nausea medications:
- Aprepitant (Emend®)
- Dolasetron (Anzemet®)
- Granisetron (Kytril®)
- Ondansetron (Zofran®)
- Palonosetron (Aloxi®)
- Proclorperazine (Compazine®)
Compazine is a phenothiazine anti-psychotic and Xanax is a benzodiazepine. The brand name Compazine is discontinued in the U.S. Generic versions may be available.
Antiemetic Medicines: OTC Relief for Nausea and Vomiting
- Bismuth subsalicylate(2 brand names: Kaopectate, Pepto-Bismol). This medicine may help treat some types of nausea and vomiting, such as from gastroenteritis (stomach flu).
- Antihistamines. Certain types may help prevent nausea and vomiting caused by motion sickness.
To Control Severe Nausea and VomitingUsually one 5 mg or 10 mg tablet 3 or 4 times daily.
Sedation is very common, and extrapyramidal side effects are common and include restlessness, dystonic reactions, pseudoparkinsonism, and akathisia; the extrapyramidal symptoms can affect 2% of people at low doses, whereas higher doses may affect as many as 40% of people.
When used in the treatment of non-psychotic anxiety, Compazine® (prochlorperazine maleate tablets USP) should not be administered at doses of more than 20 mg per day or for longer than 12 weeks, because the use of Compazine® (prochlorperazine maleate tablets USP) at higher doses or for longer intervals may cause
Less Frequent or Rare Side EffectsPhotosensitivity. Swelling, pain or milk secretion in breasts. Weight gain.
Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients.
This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery. It works by blocking one of the body's natural substances (serotonin) that causes vomiting.
Prochlorperazine is a phenothiazine (FEEN-oh-THYE-a-zeen) antipsychotic medicine that is used to treat anxiety or schizophrenia. Prochlorperazine is also used to control severe nausea and vomiting. Prochlorperazine may also be used for purposes not listed in this medication guide.
a narcotic (opioid) medication; or. medicine to prevent nausea and vomiting.
For migraine relief, administer diphenhydramine (Benadryl) 25 mg IV followed by prochlorperazine (Compazine) 10 mg IV. If the headache does not resolve in 15-30 minutes, giveketorolac (Toradol) 30 mg IV or 60 mg IM. Resolution usually occurs within 60 minutes (IM medications may take longer).
prochlorperazine (Compazine®) for Migraines. Prochlorperazine is often used to treat the nausea and vomiting and, to some extent, the pain associated with a Migraine attack. It also allows the Migraineur to rest more easily and allows other medications to work better.
Compazine is a phenothiazine anti-psychotic and Phenergan is an antihistamine. Side effects of Compazine and Phenergan that are similar include dizziness, drowsiness, anxiety, dry mouth, stuffy nose, blurred vision, constipation, swelling in hands or feet, weight gain, impotence, or trouble having an orgasm.
Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Zofran is available in generic form.
Prochlorperazine is also available to buy over-the-counter from pharmacies. It comes as a buccal tablet (dissolves in the mouth) that is used to relieve sickness caused by migraine.
No interactions were found between prochlorperazine and Tylenol. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Finally, many common drugs can aggravate RLS symptoms, including caffeine, alcohol, and nicotine; the antihistamine drug diphenhydramine (Benadryl), which is found in many over-the-counter cold, allergy, and sleeping pills; prescription antidepressants such as amitriptyline (Elavil), fluoxetine (Prozac), and
Ondansetron and promethazine are both remarkably effective drugs in controlling vertigo and the linked nausea. While improvement in vertigo was better with promethazine treatment, over time, ondansetron was more effective in resolving nausea and vomiting.
Interactions between your drugsUsing promethazine together with ondansetron can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect.
Zofran is an antiemetic (anti-nausea and vomiting) and selective 5-HT3 receptor antagonist and Antivert is an antihistamine. Side effects of Zofran and Antivert that are similar include headache, dizziness, tiredness, drowsiness, constipation, and blurred vision.
Zofran 8 mg is not a controlled substance under the Controlled Substances Act (CSA).
When histamine binds to H1 receptors in the brain, this can contribute to the body's reflex to induce vomiting. Promethazine binds to H1 receptors instead of histamine, and thereby decreases the reflex to vomit.
Zofran is often used to prevent and treat nausea and vomiting during chemotherapy and after surgery. Reglan is also used to treat loss of appetite, heartburn and early satiety (feeling of fullness). Zofran and Reglan belong to different antiemetic drug classes.
Drowsiness, dizziness, constipation, blurred vision, or dry mouth may occur. If any of these effects persist or worsen, tell your doctor.
